Secure UUID rotation is the latest security feature implemented in the Estimote Beacons’ firmware and iOS SDK that lets you disallow other people and apps from detecting your beacons. In other words, it prevents situation when another app is using your beacons for triggering actions tied to them.
First of all, UUID rotation requires beacons to have Estimote firmware version 2.2 or later. Then all you need is to log in to the beacon with your cloud account, and ‘Secure UUID’ will appear at the beginning of the beacons’ settings list.
Enabling UUID rotation causes periodic changes of the beacon’s ID (UUID, major and minor) so that it’s broadcasting unpredictable, encrypted values.
More info here: How security feature works